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ss triple helix - spring 2006,  NaPro Technology

NaPro Technology

KEY POINTS
  • NaPro Technology is a new women's health science that works co-operatively with individual women's ovarian cycles, with the aim of enhancing fertility. Blood tests and documentation of a woman's ovulation signs are the main stays of the technology, along with appropriately timed intercourse. Drugs – such as hCG and clomifene – are sometimes employed to enhance deficient phases of the ovarian cycle.
  • Originally devised from the science behind modern-day natural family planning, NaPro technology is particularly suitable for couples who find IVF unacceptable. Its strength lies in maximising a couple's chance of conceiving a viable pregnancy without recourse to procedures that are ethically unacceptable (such as embryo wastage) or that some believe violate the marriage bond (such as gamete donation).
Anne Carus introduces an ethical, less invasive approach to fertility support

Many subfertile couples have reservations about IVF. Some have concerns about the creation, manipulation, selection and disposal of early human life. Others worry about the strain that IVF could produce in their relationship, and dislike the idea of separating the unitive and procreative aspects of sex. Still others are concerned that using donor gametes violates the marriage bond. Ideally, these couples would like an approach that respects the status of the embryo whilst supporting the integrity of both the emotional and physical aspects of marriage. For some of these couples, Natural Procreative Technology could be an acceptable option.

Family planning to infertility treatments

Natural Procreative Technology (NaProTechnology) evolved from a Catholic gynaecologist's efforts to adapt Natural Family Planning (NFP) to 'difficult' groups of women – those who are breastfeeding, have long cycles or are peri-menopausal. Using the Billings Ovulation Method (where a woman detects her own fertility pattern by noticing changes in her cervical mucus) as a baseline, standardizing those observations and documenting other fertility biomarkers such as menstrual flow on a chart, the FertilityCare system for NFP was devised.[1,2]

But on reviewing the charts of couples who had subsequently failed to conceive when they wished, significant differences were noted compared with charts of normally fertile couples. Further research on these subfertile couples illustrated statistically significant differences of oestradiol and progesterone levels.

This system of accurate cycle charting provides the basis for NaProTechnology: 'A new women's health science which has as its main principle the ability to work co-operatively with a woman's menstrual and fertility cycles'.[3]

Starting out

Couples come from various reproductive backgrounds, with regular or irregular cycles. Minimum conditions for natural conception must exist: one patent fallopian tube, an acceptable seminal fluid analysis, and regular intercourse. Baseline investigations include day three FSH, LH and prolactin. If pelvic pathology is suspected, GPs are often willing to refer to NHS gynaecologists who are supportive of our approach.

Charting

Charting is taught in a supportive environment to build confidence and accuracy, and husbands are encouraged to be actively involved. Couples are taught a standardised method of observing all cycle markers and recording cervical mucus.[4] This information is not gathered in standard approaches to infertility investigation. The variations between women in cycle observations and the comparison in the same woman between cycles hold valuable clues in assisting diagnosis and monitoring response to treatment.

Advice about strategies to improve mucus, such as hydration and stress management, is given. Sometimes charting is all that is needed: some couples on the programme conceive after interpreting their individual subfertility record and using potentially fertile days for regular intercourse, a process termed Fertility Focused Intercourse (FFI).[5]

Hormonal support

If a couple's chart and tests suggest that ovarian follicles aren't developing or rupturing well, clomifene can be employed to improve follicular function. Better mucus quality can accompany improved ovulatory function. Hormonal deficiencies following ovulation, in the luteal phase, are improved with hCG injections or natural progesterone. Crucially all medication is timed to the charted events of each cycle to optimise function.

Reassessment

Once hormonally effective cycles are established, a couple's chart is reassessed.

Timescales

Couples are advised to utilise a minimum of twelve effective cycles. Treating beyond 18 cycles is unlikely to be successful. Couples are reviewed regularly and have monthly contact with their teacher, which also assists them in developing relationship skills as many are under great stress. Obtaining spiritual support from church and prayer groups is encouraged.

British programme

A British NaProTechnology programme is run from Liverpool. Forty percent of couples are Catholics, and the rest are of other faiths or none. A small percentage has previously had unsuccessful IVF.

The cost for twelve effective treatment cycles is around £1,500. This practically takes 18 to 24 months. Although expensive in terms of the required commitment, it is more cost-effective than IVF.

In Britain, over seven years, 164 couples (average age 36) with medically defined infertility (two thirds primary) have gone on to complete up to a year of treatment. Despite a miscarriage rate of around 20 percent, a take home baby rate of around 25 percent (all singletons) per programme has been achieved.

Farther afield

The Republic of Ireland programme has a twin pregnancy rate of 3.4% with no higher order pregnancies. 6 And a large international prospective study is currently investigating NaProTechnology outcomes in detail.

At the end of the day

Every infertility programme should consider its impact on couples who, at the end of the day, do not conceive. In addition to an improved understanding of the issues contributing to their failure to conceive, some couples have identified other benefits.

...helped us move from a point of frustration and confusion to a point of acceptance we could not have reached alone. (Couple with secondary infertility for six years)

Assisted reproductive technologies will continue to develop and be available for couples who feel them appropriate. However, the medical profession could be accused of not providing for the smaller group of subfertile couples for whom an ethical route is paramount. NaProTechnology could fill that void and indeed provide a possible cost-effective option for any sub-fertile couple.

Follicular and luteal variations

Progesterone and oestrogen levels are taken midluteal phase, seven days after last peak-type cervical mucus (the Peak day) rather than conventionally seven days before next predicted period. Hormonal and ultrasound studies confirm a close correlation between the Peak day and ovulation.[6,7] A 'window of fertility' surrounds this day.[8] Further hormonal investigations may be performed: pre-ovulatory oestradiols, luteal phase oestradiol, and progesterone profiles taken three, five, seven, nine and eleven days after the Peak day. Differentiation is made between early and late luteal phase deficiency, or sub-optimal oestradiol and progesterone production across the luteal phase. Some follicles don't rupture but do luteinize; others persist as follicular cysts. They may be small or have poor hormonal function, with subsequent poor corpus luteal function, resulting in reduced fertility and increased miscarriage risk.

Luteal support

Poor luteogenesis may respond to timed low dose hCG, to support each suboptimal corpus luteum. Subsequent assessment of adequate response is undertaken. Combining this approach with FFI, couples have conceived who have previously tried clomifene ovarian stimulation without success.

Follicular stimulation

Theoretically, poor luteogenesis may exist alone or may follow poor folliculogenesis. If luteal support alone does not produce hormonally effective cycles, then follicular phase support is added, usually with low doses of clomifene with the aim of achieving monofollicular, hormonally effective cycles. Couples are regularly reminded of this both before and during treatment as this is substantially different to other fertility treatments. Even in couples who have been through unsuccessful IVF, successful conception has followed mild ovarian stimulation, luteal phase support and regular FFI.[9]

KEY POINTS
  • NaPro Technology is a new women's health science that works co-operatively with individual women's ovarian cycles, with the aim of enhancing fertility. Blood tests and documentation of a woman's ovulation signs are the main stays of the technology, along with appropriately timed intercourse. Drugs – such as hCG and clomifene – are sometimes employed to enhance deficient phases of the ovarian cycle.
  • Originally devised from the science behind modern-day natural family planning, NaPro technology is particularly suitable for couples who find IVF unacceptable. Its strength lies in maximising a couple's chance of conceiving a viable pregnancy without recourse to procedures that are ethically unacceptable (such as embryo wastage) or that some believe violate the marriage bond (such as gamete donation).
References
  1. www.billings-centre.ab.ca
  2. www.creightonmodel.com
  3. Hilgers TW. The Medical and Surgical Practice of NaproTechnology. Omaha, USA: Pope Paul VI Institute Press, 2004
  4. Hilgers TW. Int Rev Nat Fam Plan 1998; 12(3):250-6
  5. Stanford JB et al. Obstet Gynecol 2002; 100 (6):1333-41
  6. Cortesi S et al. Contraception 1981, 23:635-641
  7. Daly DG et al. Fertil Steril 1989; 51:598-603
  8. Fehring RJ. Contraception 2002; 66(4):231-5
  9. Boyle P. The Medical and Surgical Practice of NaproTechnology. Omaha, USA: Pope Paul VI Institute Press, 2004: chapter 50
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